Thursday, January 12, 2017

Calling scientists to get involved in scicomm and early education

I have been very worried about the distrust of science and scientific thinking that is creeping into the public and political discourse in the US. If we do not keep science and technology at the forefront of our economic agenda, progress and innovation will stop. Most importantly, I truly believe that more scientific thinking (approaching everything around you with an open, curious and critical mind) can really make the world a better place. One solution for this is for scientists to really get out there to do outreach and education. There are days when I seriously consider quitting my job to tour the Southern and Central states of the US to speak about evolution and neuroscience and the importance of scientific thinking in general. Follow Amanda Glaze (@EvoPhD) for more on this.

I occasionally do outreach for K-12 whenever asked and I do a lot of career development activity, but I felt like I could have more impact by working with an organization. I asked Twitter if anyone could recommend programs to help me find one and boy, the science Tweeps replied!!

There were so many great programs that I thought to collect all the suggestions so that anyone else scientist or teacher trying to create new connections could benefit from this list. Please continue to suggest programs in the comments or on Twitter @TheNewPI and I will add them.

Let's get involved, people!

US programs
Global STEM Alliance (US) - New York Academy of Science programs providing mentoring for kids and young scientists locally in NY and globally
Scientist in the Classroom (US) - National Center for Science Education program to connect scientists and teachers
Science Education Partnership Awards (US) - lists and maps of all funded NIH R25 science education programs so that you can find one near you
BioEyes (US/Australia) - K-12 education programs using zebrafish as a model
Find a Neuroscientist (US/global) - Society for Neuroscience catalog of scientists willing to visit classrooms
MAD science (US) - company providing after school program (may also be an option if you think about transitioning into a full-time outreach career)
Letters to a pre-scientist (US/global) - connects scientists with kids who want to know more about science and what a scientist does
Skype in the Classroom (US/global) - Microsoft effort to allow speakers to interact with classrooms around the world

Local/university outreach program
Science Bus (CA) - after school program K2-5 staffed by the Stanford community
NWABR Speaker Bureau (North West US) - North West Association for Biomedical Research has programs for outreach and promoting science in the community
DC STEM Network (DC) - offers volunteering opportunity to teach and do outreach in the DC area
Penn STEM outreach (PA) -
Columbia University Neuroscience Outreach (NY)
Neuroscience Outreach Group at NYU (NY)

North America
Let's Talk Science (Canada) - mobilize university/college students and STEM professionals for outreach
Clubes de Ciencia (Mexico) - connect K-12 students with young scientists

Sunday, January 8, 2017

Going big for the New Year: sticking to my resolutions

Sitting in the back of an Uber in London between Christmas and New Year's, I was listening to whatever was on the radio. The newscaster announced that a new study had shown that to lose weight after the holidays you have to set unrealistic expectations. The higher the number of "stones" you set as a goal, the more weight you will lose, even if it's just a portion of the initial resolution. As I have assimilated into the American canon that a British accent makes someone more believable, I called on my inner Bridget Jones to make propositions for 2017.

I have already written about how 2016 has been productive, but emotionally destructive. My big thing for 2017 is to always Think Positive. Like that's easy, when you're an overworked, overwhelmed young investigator approaching the finish line of your tenure-track...And while I do this I want to run a half marathon.

I forget who said this, it might have been Under Armour, "When things are too heavy, you need to get stronger". I've been injured a lot while running because I neglected the conditioning and strength training that goes with increasing my distance. Similarly, I feel like my full potential as a scientist is still eluding me because I need to spend more time doing the mental work that goes with the job. The never ending admin work and constant emergencies while I'm in the lab, not only leave me very little time to truly think, but also remove me from the exciting stuff that is going on and from what I love to do. To get stronger, I have work my physical and imaginary muscles.

So what are the steps I'm taking to write a funded R01, publish ground breaking work, get my body in 10-13mi shape and overall figure out my life in 2017? Taking tips from several Tweeps and the internet.

1) BethAnn McLaughlin (@McLNeuro) recommended the Passion Planner in a blog post on Edge for Scholars. OMG, I LOVE IT! Thank you, BethAnn. While I will never ever give up my Google Calendar, having a physical book to write things in has a certain grounding effect (Think 13-yr old full of possibilities. Please add a locket on the 2018 version! I'll pay extra for it!). The most important aspect of the planner is that it doesn't need to be for appointments at all, but just for intentions. Personal, professional, philosophical intentions. It doesn't matter. It provides inspiration for guided thinking about the goals of each day, week, month. It urges you to record the small changes and successes, and to be mindful of yourself. The fact that they recommend to use colors finally provided a use for the pencils I got last year for the adult coloring books I never used. A huge plus. I've only used it for a week, but the practice to define a reachable goal for the week and write each day every good thing that happened has had a strong stabilizing influence. Even when bad things have happened around me...and they already have.

2) Veronica Cheplygina (@vcheplygina) mentioned Habitica and wrote about it in her blog. Habitica is an app that turns developing habits into a game. It's based on the concept that building habits is like building muscles and you have to repeat every day until things become ingrained. It keeps track of habits you want to form and rewards you for sticking with them every day. It's simple and cute, and I'm using it to keep motivated for my Passion Planner entries, be positive, exercise...and floss. Word to the wise, the more habits you try to change at once, the more Health points you lose if you do not check in or do your homework.

3) On the spur of the moment, through a 2-for-1 deal at the airport I picked up "Get Your S*it Together" by Sarah Knight (the author of "The Life Changing Magic of Not Giving a F*uk"). The title seemed appropriate to my current situation, and the book was easily finished in the duration of one transatlantic flight. If you like your life coach swearing you through your life-improvement experience, think of Jillian in the Biggest Loser, you'll enjoy the book. There's something for everyone, even the type-A Ms. Perfect "my s*it is all in a perfectly pyramidal pile, thank you very much" (wink, wink). Having read my share of self-help books, there was nothing new and some of the exercises are exactly what the Passion Planner has you do, but you never have enough motivation, right? P.S. The other book was The Sellout by Paul Beatty, seemingly the hottest book of the moment, by the first American to win the Booker Prize.

4) And now to the real muscles. Because I was away and the flight over was not kind to my running injury, I was desperate to find a good free yoga practice to build core strength and flexibility during the break. Google brought me to Yoga with Adriene on YouTube. The 30 days of Yoga series is great. Each session is 20-35mins and you can do two in a row if you wish. Day 6 short abs workout is particularly fierce. Since every day has a theme, I can see coming back to specific days as needed if I want a short routine or if I'm traveling. Luckily the campus gym reopens tomorrow.

OK, this is all I have. Feel free to share other tips in the comments.

Friday, December 30, 2016

2016 year in review for The New PI

And there is goes: 2016 in posts...it sucked, and I should have guessed from how it started, but I'm starting 2017 on the upswing and with a lot of hope :)
Happy New Year, everyone!!

January: This blog post has been brewing in my head for several months.
And a big one it was. By far my 2016 greatest hit with almost 4,000 reads...

February: The second R01 is done and it was very different from the first one.

March: Lately I have spent a lot of time thinking about expectations and "fit" in academia. We are interviewing faculty candidates and a huge amount of scrutiny is put in figuring out how their research and their personalities will fit with ours.

April: I'm official mid-tenure track and probably need to officially update my Twitter handle to The Newish PI.

May: With one R01 application waiting for additional experiments before resubmission and one R01 submitted, I received the dreaded email from the NIH saying that my ESI (early stage investigator) status had ended.

June: The hashtag #academicselfcare reminds you that it is your responsibility to take care of yourself, because academia will rarely do it for you.

August: "Midway upon the journey of the tenure track I found myself within a forest dark, for the straightforward pathway had been lost." (adapted from D. Alighieri, Inferno, Canto 1)

September: The more I move forward in this crazy voyage which is the tenure track, the more I realize how absolutely critical your personnel is.
2nd greatest hit of 2016

October: My R01 resubmission went from scored to not discussed. I don't know why yet, but this hit me hard.

November: I never thought that these three little words could carry that much innuendo, but "Are you happy?" turns out to be one of the most revealing and difficult questions you can ask a scientist.

December: I cannot deny that 2016 has been an annus horribilis at the personal and professional level, but I am trying to find some meaning out if it.

Saturday, December 24, 2016

Recapturing my spirit after 2016

I cannot deny that 2016 has been an annus horribilis at the personal and professional level, but I am trying to find some meaning out if it. If you have read my blog a lot of confusion and disillusionment and anger have transpired, people left my lab, grants eluded me and I became stuck in a dysfunctional situation with lots of amazing results and not enough people to do it. I felt a bit like being thrown back to the very beginning of my tenure track, but in the middle of year 4.

Yet, when I look at the year that is ending and the year ahead, the picture is not bleak and I have to thankful for it. I'm funded for 2017, so I don't really have to start thinking about possibly firing people or requesting bridge funding until this time next year. Despite everything that happened in 2016, my lab has published five papers (1 primary, 1 review and 3 collaborative), one manuscript was accepted, one more was rejected, two more collaborative papers are under review and two reviews and two large papers are at various stages of writing. So it's 8 articles in 2016 and at least 7 in the works for 2017. I am not trying to humblebrag. I need to acknowledge this to myself. I have at many points through this year felt stuck and unproductive, I felt that everything was lost and that I should just quit, while at the same time an enormous amount of work was getting done, not just by me, but by dozens of people around me. And because of this network, because of the people in my lab and my collaborators the train keeps running.

My proudest story of 2016 is about the paper that was just accepted. This was not in the cards for this year. I had found a couple mutations years ago, but apart from a gut feeling that this gene was the real deal, I didn't have enough evidence to move forward. I had entered the gene in a matching site. Yes, such a thing exists for rare disease genetics, where you get anonymously matched with other people "You're both interested in gene X. Would you like to meet in person?" In May I got a match, one more kid. We picked up the slack and started exploring the gene function in earnest. In June came another match. This time a large international group with multiple cases and a manuscript in preparation (we'll call this Group 2). When this happens and you are lucky enough to find out who the competition is, you roll your mutations into the bigger paper and move on, but the head of Group 2 was very nice "We are still finishing up some experiments, let's keep in touch and when we are ready you can join us or we can publish back to back." In July I start doing experiments like a dog and coordinating everyone in my lab to add results and Group 2 puts us in touch with their collaborators to get more data. Then a friend in the field emails me about someone else who is looking for mutations in the same gene, yet a third group working on this. Work intensifies to 150%, weeks are spent trying to understand what is going on, where everyone stands. Group 3 has more patients, great functional data, but not enough, so we join forces, co-write a kick-ass paper and submit back to back with Group 2. While the initial families had been recruited during my postdoc, I had recruited them and paid for sequencing, so I ask my postdoctoral advisor if he would agree to not be listed as a co-author to showcase that this work was done independently. He heartily agrees and fades into the sunset. Papers are in review for 2 weeks. Ours comes back with minimal comments. Group 2 gets slightly worse revisions, but we do everything we can to help and get them through. The two stories together are perfectly complementary, they have to come out together. We all get accepted! All collaborators around the world rejoice!! 26 institutions from 5 countries!!



This how I love to do science and I have stated it from the very beginning. Collaborative, open and fast because everyone speaks to each other. My holiday wish is that everyone would see the benefit of doing things like this. It's fun and you'll make a lot of friends along the way.

Saturday, November 19, 2016

Are you happy? How a simple question can be loaded

I never thought that these three little words could carry that much innuendo, but "Are you happy?" turns out to be one of the most revealing and difficult questions you can ask a scientist.  I have encountered it in so many scenarios and it can provide a lot of information independently of the answer.

Let's look at some examples.
The genuine question: How are you doing? Say you are hanging at a social at a conference and a senior faculty you know well asks the question. Depending on how much you trust them you can tell the truth, half the truth or lie, but this could be your chance to discuss issues you are having and get some mentoring and advice. If someone is truly interested in your well-being, you should take advantage of it, because at this day and age, we need all the help we can get to figure out academia, the job market, the funding agencies and just how to live life in the "post-truth" era...

The hidden question: Are you interested in moving? At the aforementioned social you bump into a faculty member whom you know marginally well or not at all. If they are looking for new faculty and are interested in what you do "Are you happy?" is the easiest way to gauge whether you would be moveable. Anything less than a resounding "I really am. I love it there." will give them a hint that there could be trouble in paradise. Of course the right answer is "Eh, I guess so", as "I hate that horrible place. Please get me out!" may not be the right strategy to find another university. Or to negotiate a killer start-up package.

The trick question: Say that you're okay! This happens when a senior faculty asks you the question in front of another senior faculty at your institution. At which point your brain is racing at a million miles an hour to regain composure and instead of glaring at them "Why are you putting me in this position?!", you quickly say yes and divert attention to how abysmal NIH funding is right now.

The probing question: Am I going to be happy? Very few people ask this all important question at job interviews, but I think it could be critical to figure out what is really going on at an institution. During interviews, the faculty you meet is in recruitment mode and has to show the best possible side of their university. The unhappy people are temporarily hidden in a closet. The people you will meet agreed to recruit and sometimes they couldn't say no, but if they are not happy, they have been hiding it. It will take a very skilled actor to crack a wide smile and answer "I love it here", if they are lying. Of course, you must take answers with a grain of salt. Some people are never happy, no matter where they are and recognizing the Debbie Downers may be difficult. But if someone changes the topic "I really like the city" and has nothing good to say, there may be a problem. If multiple people hesitate before answering, there may be a problem. And in some cases, people who are moderately happy may volunteer some of the issues they are encountering, which, if you decide to take the job, will prepare you in advance. All universities have some kind of issue, but coming in with some idea of what to expect may help.

Hope this helps to find your happy place...

Sunday, October 30, 2016

Requiem for my 2016 dreams

My R01 resubmission went from scored to not discussed. I don't know why yet, but this hit me hard. My program officer had been very supportive of the first submission and had given me specific advice on how to address the reviewers' comments. We did a year of work and added everything they requested adding all the modifications they wanted. In this day and age you cannot ever think a grant will get funded, but I was sure it would get scored, that by following the instructions of the PO and the study section I would be able to adjust my aim (pun intended) and at least improve.

I was utterly shattered. Shattered because of the self-doubt that no matter how much work I put into it, I will never make the cut. Shattered because after submitting at 3 consecutive NIH cycles, I do not have the strength left in me to pull together a brand new application for February. But then, after the initial shock, I realized I was shattered mostly for one reason, that my dream of going back to the job market this cycle has been quashed. I have been very unhappy for a long time and each NIH submission comes with added weight that, in addition to possibly getting me tenure and bringing some stability to the lab, an R01 may start the process of breaking me out. I don't like who I am right now: exhausted, angry, frazzled, always rushing, so busy that I don't have the time to mentor my people as I would like, and most importantly so mentally drained that I cannot take the time to enjoy the science any more. This is not who I want to be. I don't want to feel a weight in my chest every day when I walk into my lab building. I hate that my happiest moment every month is when I walk out to leave for a trip. This is hurting my lab, my science and my health.

The reasons why I want to quit are the usual ones: I don't feel like the university is the right fit for me, I feel isolated, ungrounded and organizational issues make my life impossible. Some issues I could have figured out during the interview process, if I had known which questions to ask, but others evolved over the years. Things keep getting worse, instead of better, and at some point I disenfranchised myself, I stopped trying to affect change. I have been running so that the endorphins get me through the day, but I've been riddled with injuries for the past year. I have tried to run through the pain as much as possible, but the pain right now is too much even to do yoga. So not running has also contributed to declining mental health.

Which brings me to a reality of academic life. A lot of our stress in addition to practically having to run a small business for an education corporation, comes from the length of our transitions. Getting a faculty job takes 1-3 years and this alone generates sustained stress, which can be become punishing of you are in a difficult situation. Transitioning to an alternative career can also take a while because new skills may be necessary. I am writing things that you are not supposed to write, because I have spoken to a lot of friends about my situation and theirs, and I know I am not alone. I think this is, in a way or another, similar to how a lot of your faculty feel right now, and many examples were given in a Nature feature on early career researchers this week. I wish I had a solution. I wish I didn't think that our generation may be lost. The worst part is that everyone I talk to is so upset that we are all amplifying each others' emotions to the point that talking to friends does more harm than good.

Being upset and angry at this point is crippling and counterproductive. A year and a half ago, when I realized I really needed to get out, I put down on paper what I want in my life and road map to reach my goals, so I went back to read that. I realized I had given myself a deadline which is still in the future, and I still think it is reachable. So, what to do now? I made an appointment with a sports medicine doctor. I found the contact of a good therapist in the hope that they can help me develop better strategies to deal with work for another year and help me figure out whether academia is really what I want. But most importantly, I need to find a way to regain my love of science...and to do that I need to engage more with the people in my lab and take my time to actually think, read and do science. A friend who just came out of study section told me "Getting grants is a lottery. The name of the game is resilience." I'll work on that and see what happens in 2017...

Saturday, September 24, 2016

The emotional toll of the "NIH running wheel"

There are few posts in my queue right now, that will never see the light of day. They were born our of anger and confusion and anxiety laced with a hint of depression. I suffered from severe pre-menstrual depression my entire life, and until I found the right medical team, every time I randomly felt despair and the desire to curl up in a ball and wail, I had to ask myself two questions: "Is this emotional reaction appropriate to the current events in my life? What day of the month is it?" If the reaction was "not appropriate", I usually had to ride out the next 24-48 hours before my brain magically reset itself back to normal (Someone should study this, because it's crazy fast. Literally like a curtain lifting). So as my life started spiraling out of control in the past few weeks, my safety questions came back to me with a slight variation "What time if the year is it?"

While it's a different cycle, the NIH cycle is as bad as the menstrual one. Especially, if you are on the running wheel of submitting a grant every cycle, which means having a grant reviewed every cycle as you are writing the other one. I haven't quite recovered from the meltdown in June (post here), which was on the heels of the February one, and here comes the October deadline. Last cycle my R01 was due the same day the other R01 was being reviewed. This time I'm on three R21s for October. Yup, you've heard this right. Three. And my R01 is being reviewed at the end of the October. Because for some reason, all my study sections tend to cluster as close as possible to the resubmission date, so that there is no hope I could skip a cycle. As my other funding gets close to the end, and the pressure increases for keeping the lab going, every grant generates more and more anxiety. The more you submit, the more it feels like there is no rhyme or reason and you just have to do your absolute best and hope that your proposal will fall in the right hands. The closer the study section date gets, the more you start second guessing what you have already sent in and you find all the flaws in your mind. Positive thinking and negative thinking run a strange relay in your head, when you want to believe the grant will be funded, but you want to prepare yourself for the worst at the same time, so you kind of go for the middle ground "All I want is a score!" I hate you running wheel!! (Waving fist to the sky)

So more and more yoga. And maybe I should pick up Transcendental Meditation...or drinking. What I should really be doing now, is writing.

Tuesday, September 13, 2016

Tales of postdocs past: what did I learn?

The more I move forward in this crazy voyage which is the tenure track, the more I realize how absolutely critical your personnel is. I have posted recently about some setbacks in my lab and having to pick up the pieces after some unexpected departures. Some of my readers wanted some more detail. I am not going to go into specifics too much. What I can say is that this year I have lost all three postdocs, each for a different reason. One was not a good fit and decided to quit before I had to drop the axe, one was poached away from a biotech company, and one had to leave because of family obligations. None if them had reached the three year mark in their tenure and none of them will be able to see their major project to completion. The saddest part of this is that one was awarded an NRSA fellowship from the NIH and we had to give the money back. Just the thought to give money back to the NIH makes my heart sink every time! I had to do my best to apologize to the program officer with the hope that this will not held against me in the future.

I have been racking my brain trying to figure out why this happened. Whether in addition to extraordinary bad luck, there is something that I have done to make the environment inhospitable, or to just pick the wrong people for the job. The thing is, at least two were not wrong. Between the two of them, they produced data for at least four good papers in two years. So what would make a productive scientist with exciting data, give up? Part of me is afraid that they see what I am going through, despite my desperate attempts to screen them from the vast majority of what I have to do, and they realize that they do not want my job. Another part of me thinks that, because I do so much career development and planning in the lab, I am pushing them to explore alternative careers and shooting myself in the foot at the same time. Yet, I had so many conversations with friends on whether it is even moral to hire postdocs nowadays and tell them that a career in academia is the only option. Getting into the ivory tower is harder and harder, and once you are in, it does not get easier. As a mentor, I cannot and I will not leave them ill prepared for what is out there.

My question is: Could this have been avoided? When I think about what pushed me forward all these years, don't laugh, it all comes down to my postdoctoral theme song. Yes, I have theme songs. My PhD song was Fighter by Christina Aguilera (if you listen to it, think as if it was addressed to my thesis committee. It'll be funny). My postdoc and current song is Remember the Name by Fort Minor. The key here is the refrain: "This is ten percent luck, twenty percent skill/fifteen percent concentrated power of will/five percent pleasure, fifty percent pain/and a hundred percent reason to remember the name". If this doesn't describe academic science, I don't know what does. The "concentrated power of will" bit in particular, because there are days that razor-sharp uncompromising concentrated power of will is the only thing that makes me to get out of bed and keeps me going. I see it in many of my colleagues and I wonder whether this attribute, more then anything else, is what keeps academia afloat. A semi-deluded cultish sense that "I will not ever stop asking questions and pushing forward". I don't know whether you have to be born with it or whether it can be cultivated. I have not trained enough people to know and I have not figured out ways to test it. Hope Jahren in her autobiography Lab Girl describes a Good Cop/Bad Cop routine where every new student is made painstakingly label hundreds of tubes for sample collection, and then put through a lengthy discussion on the project for said tubes that ends in all the tubes going into the trash. If, instead of moping, the student responds to the exercise by happily labeling tubes for the "new and improved" project, s/he is a keeper.

How do you find someone with skill, power of will, luck and high pain tolerance? Is this really what it takes? I cannot fault any of my former people, because in the end they decided what was best for them. But, if the current funding climate is pushing promising young people out, how do I reset my expectations for running the lab?

Thursday, August 25, 2016

Redefining expectations: I'm a PI now.

Today should have been a good day...
A very nice review article which took a lot of effort in the past couple of months was accepted and for the first time I saw my name in print in Science. Granted this was my collaborator's paper, so it's not from my lab, but it's pretty sweet CV padding. My department chair will like it. Plus, one of my postdocs told me about some pretty spectacular data which we are hoping will lead to a major publication from my own group. Yet, I was miserable and almost closed my office door to curl in the fetal position and cry. And know one thing, reader, I'm not the type of person who cries. When I cry, people who know me tend to freak out, because something major must be catastrophically wrong.

The Shining screenplay.  By William Beutler  [CC BY 2.0
(http://creativecommons.org/licenses/by/2.0)],
via Wikimedia Commons" 
So, what is so wrong? This summer multiple people quit the lab, leaving me understaffed and we need to finish a paper, so I had to get back to the bench and step in to help with experiments. This paper/project is under very strong competitive pressure and through false information I thought we were getting scooped, so I have put in back to back 80hr weeks to try and finish it. I have been mostly alone in the lab up to 10-11pm every day. We have done a lot of stuff, but one critical experiments will be delayed by a couple of weeks because I overlooked some details and some things need to be redone. I have regressed...I'm back to my grad school hours, occasionally wearing my grand school clothes, feeling the pressure of my life and my lab depending on this project. And then it hit me. "What am I doing? I'm not in grad school! My life and my lab do not depend on this project. I'm supposed to be writing 2 grants on the other super cool project my postdoc was telling me about."

If we cannot finish experiments in time I had already agreed with our collaborators that we will fold our data into their paper instead of going back to back. And then I will have a ton of extra data to get a lovely study out. My postdoc's project, which will be finished in the next month, will lead to another paper. And this second project is more likely to get me tenure than anything else I'm doing. Plus we just published in Science...Why was I upset, again?

I was upset because I fell into the mental trap of putting all my professional eggs in one basket. As a student and postdoc this is a common trap, thinking that your career depends on one project, one major paper, one checklist item checked off after another. Getting stuck in an obsessive rut that your life sucks. The thing is, it doesn't. This is all in your head. There are multiple career paths and multiple ways of moving forward. But when you work so much that you need to prop yourself up to keep going and you're exhausted, you're bound to flawed thinking. I'm not a postdoc, I have 6 or 7 baskets at the moment and I have to decide how to distribute my eggs. I have neglected my physical and mental health for this project, and I am too worn out to deal with anything else. This was a mistake. I cannot carry the entire lab on my shoulders and finish every single experiments and run everything. This is not sustainable. Sometimes, all you need is a change of prospective...regroup and objectively see where you stand. Objectively, things are going pretty well and I should just go on vacation.

Tuesday, August 9, 2016

"Midway upon the journey of my tenure-track..."

"...I found myself within a forest dark, for the straightforward pathway had been lost." (adapted from D. Alighieri, Inferno, Canto 1)

The past week has been tough, but also a recuperative one, desperately trying to gather some energy both physical and emotional to deal with pulling the lab together one more time. I have been battling burnout for months, but I was fighting to keep one of the projects in the lab alive. Due to a couple of toxic hires part of the project was recently scooped and another big part is under extreme competitive pressure. Because the bad hires are now gone, I need to pull a paper out of thin air by myself working with some of the new people who just joined the lab.

Despite this I was finally starting to feel secure in my tenure track, I was going to pull this project together and another big part of the lab was running smoothly with the promise of continuity. The goal of having a cohesive body of work by year 5 (1.5 years away) seemed possible. It finally felt like the lab was hitting a positive stride after being wobbly in the Spring. Then multiple disasters hit in rapid succession. One R01 application which had taken an ungodly amount of energy to coordinate and pull together fell flat leading the Program Officer to recommend to just write another grant. Samples I had been trying to secure for months failed to materialize killing a whole new exciting direction in the lab. Then I found out that all the personnel leading the only viable project we have is going to be gone by the end of next month without any of the papers being completed. WTF?!

Now I have to run the lab, deal with a packed travel schedule for the Fall and be primarily responsible for 4 major publications with no manpower or manpower with limited expertise. I feel like I'm standing on a boat watching my projects drown and having to decide which one should be saved, because I cannot possibly try to rescue them all. It's heartbreaking and a little terrifying. "What if I pick the wrong one?" Year 3-4 in the tenure track is that defining moment where you feel like your career should take off and as I was preparing to take that leap, I was hit by ton of bricks. I am gasping for air.

In the middle of all this, I got to take break thanks to a conference tied in with a visit to a friend's institution and to my old postdoctoral lab. And the upshot from talking to multiple friends was "Boohoo, this happens to everyone." "If this was easy, everyone could do it." "You think you have it bad, my student graduated and went to Nepal for 6 months with no email access." So basically, shut up, get your shit together and finish the papers. God, this job is hard! I'm realizing that to just survive you have to be made of steel. The more I go on, the more I feel the steel getting tempered.  At the same time it seems like everything is going against my generation: the crazy-low funding rates, the scarcity of jobs. We were sitting at this meeting watching talks from fancy HHMI investigators presenting 20 transgenic mouse lines and we were just like "Sure, I could do that if I had the money, but I don't, so I can't"...and watching these massive projects, you wonder if in your little lab with a revolving door of trainees (some good, some bad), you will ever be able to do something significant. Or even if this roller-coaster of emotions will ever stop.

In any case, back in the lab shit must be pulled together, projects must be finished, so I need to get back to the bench full time and everything else will have to wait. As Winston Churchill once said "Success always demands a greater effort". So 150% effort, here I come!

Thursday, June 30, 2016

When your trainees get grants everyone wins!

There is nothing quite as exciting as your trainee getting their own money. Apart from the obvious financial benefit to the lab and a lessening of the burden to support everyone's salary and fringe, the real relief is that you start feeling like the lab is viable and that you are actually considered as an independent scientist by your peers. Of course, getting an R01 form the NIH is the litmus test of your peers believing in what you do, but fellowships are a sign that you are deemed worth to train the next generation. The projects in the lab have enough legs to bring in money for multiple people. The trainee is happy, you are happy. Everyone wins!

So new PIs do not think believe those who say that you need to be established or have an R01, to get your lab peeps funded. Write a comprehensive mentoring plan identifying training objectives AND find an experienced co-mentor, then keep trying. I like this list from Berkeley to get you started.


Tuesday, June 21, 2016

Remembering academic self-care

The Scream - E. Munch (Google Art Project)
The hashtag #academicselfcare reminds you that it is your responsibility to take care of yourself,
because academia will rarely do it for you. Multiple people, including the wonderful @IHStreet, have spoken bravely of the struggles with psychiatric illness we encounter as academics. It's not clear whether the constant stress eats away at our well-being or whether scientists are just more neurotic because of their constantly inquisitive nature. Many if not all of us, at some point will deal with unbearable stress, lack of self-worth, depression and anxiety.

As far as depression goes, I think I have the best kind. It comes linked to major life events or hormonal changes and once identified, it is rapidly improved by standard medication. After multiple years of therapy, I'm pretty good at figuring out what is going on. Basically the drill is "Why am I so hopeless?" "For how long have I felt hopeless?" "Oh, maybe serotonin has gotten a bit wonky and needs a boost. I need to talk to someone about this." Exercise has also been very good at dealing with this when I feel things are not quite right. As I said, the best kind.

Still as lucky as I think I have been, depression is not an easy thing to go through and you cannot just "pick yourself up and snap out of it". It has impacted multiple years of my life and nowadays I monitor its comings very closely. For some reason the winter messes with me (cough, SAD, cough) and the summer NIH deadline has had me staring right down the abyss the past few years. I have very strong feelings about my future depending on how well I can convince a random group of invisible people. This winter was particularly bad for personal and professional reasons and I started wondering whether I'm burning out. A recent Harvard Business Review article on incipient burnout quoted
- "emotional exhaustion: feeling used up emotionally, physically and cognitively"  CHECK
- "easily upset and angered, have difficulty sleeping" CHECK
- "depersonalization, feelings of alienation and cynicism toward your job"  CHECK
- "capacity to perform is diminished as is your belief in yourself" CHECK

This sounds dangerously like some aspects of depression and for me one leads readily to the other. Since there are some actual problems that need to be solved in my job and life, what matters most is that I am healthy enough to do it. So, it's #academicselfcare time! I have not had an actual vacation (when I'm not writing a grant or doing a substantial amount of work on the side) in something like 18 months and I do not remember the last time I had a two-day weekend. The summer I started my postdoc I pledged I would take both Saturday and Sunday off each week for two months. The first weekend I just sat at home and watched 12 hours of TV each day because I had no idea how to plan weekend activities any more. Things are not as bad now as in grad school because I have learned to introduce downtime whenever I need it, but I feel like I need to get back to a regimented rest schedule. Once you become a professor, it is very easy to move things that need writing and thinking to the weekend because your day is so fragmented and interrupted by random things, you cannot find 2-3 hours of peace. So if you want to have downtime in the evening, you move certain chores to the weekend. The thing is, I just need to lock people out and protect my time during the week.

Here I pledge that I will have full weekends (and maybe 3-day weekends) in July and August, that I will plan a couple of kick-ass trips and that I will carve out some time every week to write and read (OMG, read!?) and do science-work that will actually push my research program forward. Oh, yes and get back to exercising regularly.

Tuesday, May 31, 2016

The first rule of Academic Speakeasy...

Academic Speakeasy will be a monthly appointment to privately and anonymously discuss academic life and struggles (see blog post). This is how it's going to work.
  • 5 minutes before chat start time @Professor_Chat will post the link and password for the Niltalk chat room 
  • you can choose whatever name you like: your real name, your Twitter handle or a different name every single time
  • in the chat room DO NOT CLICK the "Dispose" button. Niltalk is set up so that every member can cancel the chat at any time. Please, let the moderators do that
  • we will chat for an hour or less about the topic (for the first time about how to set up)
  • be courteous, be constructive and feel free to share
  • the Niltalk chat will be destroyed as soon as it ends and no record will be kept
If you are also interested in an open chat on Twitter post topics on @Professor_Chat and we'll try and make it happen.

How do we build a secret advice network for scientists?

In the past few years I posted several times about the struggles I'm facing in academia. I am always
really scared of putting my thoughts out there, but the thought that this could help other people always make me click on the Publish button. The responses have been in general very positive expressing support and gratitude for sharing. While we often believe that we are unique snowflakes in our sorrows, we really are not and many scientists at different stages of their career have similar problems.

Multiple times on Twitter and on the blog people have expressed the need for a forum to meet and talk about our professional issues. I am fortunate to have a good cohort of new investigators who meets regularly to discuss what is going on and come up with hacks to get around administrative hurdles. But there are thoughts I cannot share with colleagues at the same university and sometimes I would like to learn how things are at other places or how different people solve problems.

After some thought on how to do this and some discussion with @drosophilosophy, aka Tim Mosca, who most recently raised the issue, we really like the format of Diversity Journal Club #DiversityJC on Twitter (run by the awesome @Doctor_PMS, @IHStreet and @DrEmilySKlein). They set a time once a month to discuss an issue on Twitter. Since Twitter is still a public forum, I have been looking for a private password protected chat room and I discovered Niltalk. Niltalk allows you to create a password for a room that exists for only 2 hours and then gets deleted forever. Think of it as a speakeasy! Users can be completely anonymous or not, as they prefer. We can just set a date and time, decide on a topic or a couple of topics and open as many chats as we like. Each topic should have a moderator (myself, Tim or ideally the person proposing the topic would be willing to moderate). There could also be a monthly chat on Twitter about academic career development, with a common hashtag like #profchat and this could be storified to provide a more permanent record.

I'll start one tomorrow June 1th at 10pm EST (7pm PST) just to see how it works and start the conversation. Link for the chat room and password will be posted on Twitter at 9:55pm on a dedicated Twitter account @Professor_Chat
Come hang!!

Friday, May 27, 2016

How do you know when to change and not quit?

I have been thinking a lot about quitting recently. As I wrote in a very hopeful post the day before I started my faculty position, thinking about quitting is part of my process. I have considered alternative careers since I was in college and I have become accustomed to chose my job every day. I am going to work because I want to, because there is nothing else that I would rather do. Sometimes things get so hard, that you question your choices and wonder whether whatever you are doing is really what you should be doing with your life.

I was looking for articles or blog posts about transitions in academia and I found a whole lot about quitting. There is a great article on Vitae that summarizes some of the views of the so called academic Quit Lit which they collected in a handy Google doc. (Warning: you should read these posts only when you are in a good mood or in the company of a good bottle of Scotch)

However, what if you should not change careers altogether, but are just unhappy where you are?
Sometimes we mistake profound dissatisfaction with our current situation with having chosen the wrong profession, but this is not necessarily true. Throughout my training, I have met people who just needed to be somewhere else and did not necessarily fit where they were. Someone who started a PhD in Neuroscience and switched to Computer Science to another university. Multiple people who were in the wrong thesis lab or the wrong postdoc lab. When you think everything is hopeless and you are stuck, this is hardly ever the reality. You are never ever stuck unless you're in jail without the possibility of parole, but then you have other problems than deciding what to do with your PhD.
You can be unhappy for a multitude of reasons:
- your job is toxic and your boss is a monster who makes everyone cry;
- your job is great/okay, but the rest of your life sucks;
- your job is okay, but you do not have the right resources for advancement.

It boils down to this. You institution/lab can 1) destroy your career, 2) allow your career or 3) support your career. If you're in position #3, great for you! Stop reading and go do something fun. If you're in position #1, you need to come up with an exit strategy stat! In the best case scenario you are a year 1-2 grad student or postdoc and you can exit gracefully to find another lab. In the economy of your life, 1-2 years mean nothing. Trust me. If you are more advanced, you need to discuss with trusted colleagues and mentors how to best position yourself to get out. A good number of people will be in position #2, some things are okay, some things are not, so you're not sure what to do. Science has a lot of ups and downs. You may just need to sit down and figure out the pros and cons of your situation. A senior mentor recommended a very good strategy. Make a list of every single thing that is important to you in your life and your work, for example, good colleagues or good museums. Then as you consider moving, rank the new cities and universities for each of the criteria (this may require research). The perfect university/perfect city match may not exist, so you must decide what you can live with and what you really want. It may turn out that where you are is the best compromise or that you can ask for something to change to make things better. If not, you use your network to start figuring out how to move somewhere higher on your list. Academia can be for life, but does not have to be a life sentence.